DOS Plus may refer to
- DOS Plus - CP/M-based operating system by Digital Research that has comptibility with PC-DOS
- DOSPlus - TRS-DOS variant produced or retailed by Micro-Systems Software Inc.
- DOSPlus IV - TRS-DOS variant produced by Micro-Systems Software Inc for the TRS-80 Model IV
- DOS+ - BDOS replacement for CP/M 2.x.